Thioamides in the collagen triple helix.

نویسندگان

  • Robert W Newberry
  • Brett VanVeller
  • Ronald T Raines
چکیده

To probe noncovalent interactions within the collagen triple helix, backbone amides were replaced with a thioamide isostere. This subtle substitution is the first in the collagen backbone that does not compromise thermostability. A triple helix with a thioamide as a hydrogen bond donor was found to be more stable than triple helices assembled from isomeric thiopeptides.

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عنوان ژورنال:
  • Chemical communications

دوره 51 47  شماره 

صفحات  -

تاریخ انتشار 2015